This signal transduction is governed, in large part, by post-translational modifications that alter protein activity, stability, and localization, as well as the formation of higher-order macromolecular complexes. Editor's evaluationĬells respond to external stimuli by activating a finely-tuned cascade of enzymatic reactions and protein-protein interactions. This specificity profiling platform will shed new light on phosphotyrosine signaling and could readily be adapted to other protein modification/recognition domains. Finally, we expanded our method to assess the impact of non-canonical and post-translationally modified amino acids on sequence recognition. We extended this platform to the analysis of SH2 domains and showed that screens could predict relative binding affinities. These screens recapitulated independently measured phosphorylation rates and revealed hundreds of phosphosite-proximal mutations that impact phosphosite recognition by tyrosine kinases. We also screened several kinases against a library containing thousands of human proteome-derived peptides and their naturally-occurring variants. We screened several tyrosine kinases against a million-peptide random library and used the resulting profiles to design high-activity sequences. Here, we present a platform that combines genetically encoded peptide libraries and deep sequencing to profile sequence recognition by tyrosine kinases and SH2 domains. Although the preferred recognition motifs of many kinases and SH2 domains are known, we lack a quantitative description of sequence specificity that could guide predictions about signaling pathways or be used to design sequences for biomedical applications. Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities that depend on the amino acid sequence surrounding the target (phospho)tyrosine residue.
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A career delivery driver with 20 years … I wish I could do a zero star. Note: For Amazon Punchout orders, you can only set location preferences. I was told the package was there and will be waiting for me the next day. On Decemmy fiancé and I had two packages that were marked as delivered by LaserShip that NEVER ARRIVED. I do not understand why any reputable company would use Lasership. Reviewers complaining about LaserShip most frequently mention customer service, front door, and next day problems. Their main focus is to get the packages attempted and make money. My online order was split by yall into 2 shipments. It provides same-day and next-day delivery services in select regions across the country. Since Covid-19 Drivers have been wearing masks and not asking you to sign for delivery, but would knock on your door to alert you of your delivery. That’s what happens when you attempt to run on the trail but it’s covered … More LaserShip reviews & complaints. One time the tracking says delivered but I didn't receive shit, two days later it suddenly appeared. Delivery could not be completed - Unable to leave package. Lasership shipping services is a terrible company that doesn't value its customers. And once I contacted Amazon (they told me to wait for 2 days before taking action), the rep offered free overnight shipping for a new order and refunded me for the first order. To contact the OnTrac support team, text (302) 246-7136 and an OnTrac representative will be happy to help. Also, Amazon employees hate lasership with a passion. This is the worst company I ever dealt with. Be careful using lasership because they stole my sneakers but good thing Nike refunded me. Why did Amazon stop using UPS? Amazon is suspending the service because it needs its people and capacity to handle a surge in its own customers' orders, according to a person familiar with the matter. Is there any way to stop Amazon from sending my packages via Lasership? Yesterday Lasership claimed they delivered a Prime Package at 7:54 p. I live in an apartment building with a ring doorbell. Lasership was supposed to deliver my 2-day delivery package from Walmart. Regional carriers like LaserShip have been a major. Tracking a Lasership package is a very similar procedure to that of many logistics companies. They did NOT the driver would have had to ring my … The Tennessee service will increase LaserShip’s overall delivery coverage by 18%, the company said. So it’s not like they offer free shipping and they’re trying to go with the cheapest carrier, they’re charging AND using this theft ring disguised as a delivery company. The packages never show up and it takes too long to get a refund. LaserShip ranks 446th among Shipping sites. LaserShip - Customer service lies to customers all the time! Lasership is bad, but Amazon's customer service is GREAT. LaserShip - Customer service lies to customers all the time! LaserShip - Shipping Can you stop using lasership?! It is the worst company. … Find helpful customer reviews and review ratings for Cherioll Hemorrhoid Cream, Haemorrhoids Treatment, Hemorrhoid Relief,for Hemorrhoids Fissures Bleeding, 20g*2 (Assistant tub 4Pcs) at Amazon. We'd recommend … About Services Menu Toggle. Unfortunately, we don't have a way to pick which carrier is assigned to our orders. The Lasership van suddenly … amazon needs to stop using lasership. I think HelloFresh or one of those companies uses them now. Specialties: Founded in 1986, LaserShip is a parcel carrier facilitating last-mile delivery to the eastern U. Hi! Amazon works so well on so many levels. What did I get for switching a missed delivery date and a redelivery attempt. Fast and free shipping free returns cash on delivery available on eligible purchase. what does exception mean lasershipdid doubling down with the derricos get cancelled. 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The rulers are offset from each other, because I'm trying to show the lengths of the slots. Here is the June Tailor Shape Cut Plus ruler next to the original Stripology ruler. If you have a problem with rulers slipping while you are cutting, you'll love the Stripology rulers, after you get it lined up correctly on the fabric. With the Stripology rulers, there is no nudging, that ruler isn't going anywhere, at least not without messing up your layers of fabric. With a June Tailor ruler, I can nudge it into position because there isn't grip on the back of the ruler. I always lift up a ruler to reposition it on fabric, but on huge rulers like these, it's pretty easy to lay it down a little crooked. The Stripology rulers have a LOT of grip on the back, which honestly, I kind of hate. Now, there are multiple aftermarket options for adding grip to your rulers, so to me, that's not a big issue with the June Tailor rulers, but then, I have no problems holding the rulers with no added grip. They slide across the fabric, and if you don't hold them correctly, they will slip and mess up your cut. June Tailor rulers have no grip on the back. Another issue with thinner vs thicker plastic is weight, the Stripology rulers are much heavier, so if that's an issue, now you know which is heavier, which is lighter in weight.Īnother major difference in the rulers is the grip. So as far as durability goes, I am going to say Stripology wins, but you are going to pay for that, so if money is your main consideration, you will have to decide whether you'd rather pay more less often on Striplogy rulers, or less more often on June Tailor rulers. JoAnn does not carry the Stripology rulers, and you rarely find them on sale. JoAnn Fabrics routinely have the June Tailor rulers on sale or you can use a coupon if they aren't. That said, June Tailor rulers are also much cheaper than the Stripology rulers. I actually taped it back together and still use it as a backup, but with the thinner plastic I would think a break from falling is more likely on the June Tailor rulers. Also, one time I dropped a brand new June Tailor ruler and broke the corner off. Most I've simply worn out through using them so much, and eventually, on a slotted ruler or really any ruler, you will wear away enough of the enough of the edge that the ruler can no longer give you an accurate cut. I've gone through several over the years. June Tailor rulers are made of much thinner plastic that the Stripology rulers. I'm going to try to compare the rulers most similar in style and function, but first I'm going to give you some basic differences in the rulers. Patinas can also be found in woks or other metal baking dishes. This type of patina is formed by corrosion, what elements the air might hold, residue from the wear of the carbon brush, and moisture thus, the patina needs special conditions to work as intended. Patina is also found on slip rings and commutators. The dark color of the statue made English sailors call the square that houses it "Black Horse Square". The same statue in 2015, after removal of the patina (2012–13), showing the original 1775 finish. This patina is water-soluble and will not last on the outside of a building like a "true" patina. A patina can be produced on copper by the application of vinegar ( acetic acid). More simply, the French sculptor Auguste Rodin used to instruct assistants at his studio to urinate over bronzes stored in the outside yard. Sometimes the surface is enhanced by waxing, oiling, or other types of lacquers or clear-coats. Some patina colors are achieved by the mixing of colors from the reaction with the metal surface with pigments added to the chemicals. Colors range from matte sandstone yellow to deep blues, greens, whites, reds, and various blacks. For artworks, patination is often deliberately accelerated by applying chemicals with heat. The basic palette for patinas on copper alloys includes chemicals like ammonium sulfide (blue-black), liver of sulfur (brown-black), cupric nitrate (blue-green) and ferric nitrate (yellow-brown). For copper alloys, such as bronze, exposure to chlorides leads to green, while sulfur compounds (such as " liver of sulfur") tend to brown. Patination composition varies with the reacted elements and these will determine the color of the patina. They are often used by artists as surface embellishments either for color, texture, or both. The process is often called distressing.Ī wide range of chemicals, both household and commercial, can give a variety of patinas. See also: Copper in architecture § FinishesĪrtists and metalworkers often deliberately add patinas as a part of the original design and decoration of art and furniture, or to simulate antiquity in newly made objects. The chemical process by which a patina forms or is deliberately induced is called patination, and a work of art coated by a patina is said to be patinated. Figuratively, patina can refer to any fading, darkening, or other signs of age, which are felt to be natural or unavoidable (or both). The word patina comes from the Italian patina (shallow layer of deposit on a surface), derived from the Latin patĭna (pan, shallow dish). It also refers to development as the result of weathering of a case-hardened layer, called cortex by geologists, within the surface of either a flint or chert nodule. In geology and geomorphology, the term patina is used to refer to discolored film or thin outer layer produced either on or within the surface of a rock or other material by either the development of a weathering rind within the surface of a rock, the formation of desert varnish on the surface of a rock, or combination of both. This has led stone tool analysts in recent times to generally prefer the term cortification as a better term to describe the process than patination. Īrchaeologists also use the term patina to refer to a corticated layer that develops over time that is due to a range of complex factors on flint tools and ancient stone monuments. Patina also refers to accumulated changes in surface texture and color that result from normal use of an object such as a coin or a piece of furniture over time. In common parlance, weathering rust on steel is often mistakenly referred to as patina. On metal, patina is a coating of various chemical compounds such as oxides, carbonates, sulfides, or sulfates formed on the surface during exposure to atmospheric elements ( oxygen, rain, acid rain, carbon dioxide, sulfur-bearing compounds). They may also be aesthetically appealing. Patinas can provide a protective covering to materials that would otherwise be damaged by corrosion or weathering. The patinas on leather goods are unique to the type of leather, frequency of use, and exposure. Patina ( / p ə ˈ t iː n ə/ or / ˈ p æ t ɪ n ə/) is a thin layer that variously forms on the surface of copper, brass, bronze and similar metals and metal alloys ( tarnish produced by oxidation or other chemical processes) or certain stones and wooden furniture (sheen produced by age, wear, and polishing), or any similar acquired change of a surface through age and exposure.Īdditionally, the term is used to describe the aging of high-quality leather. The external layer has been weathered by moisture and rain, leading to the oxidation of copper. Pre-colonial copper coin formerly used in the Copper Belt ( Democratic Republic of the Congo and Zambia). View all of the Education Benefits available to you How do I apply for ROTC Scholarships?Īrmy ROTC has several scholarships available for college-bound high school students. There are a variety of options available to help you pursue education with flexibility, such as ROTC programs, the GI Bill, and other programs that help pay for college tuition, trade school, technical school, or trainings. How can the Army help me pay for college? Learn more about Army Eligibility Requirements and how to receive Officer training while in college. Military Academy at West Point, or from another college or university program. To become an Army Officer, you must be at least 18 years old and have a college degree obtained either through ROTC, U.S. To become an enlisted Soldier, you must be 17 years old. Questions you may have right now How old do I have to be to serve in the Army full-time? What type of health care jobs are available in the Army?Ĭan the Army help me pay for medical school? How can I prepare for the conversation?Ĭan I join as an Officer? Will I be expected to join if I talk to someone? What will you ask me?Ĭan I join as an Officer? How can I prepare for the conversation? One of our recruiters will either call or email you to set up time to talk. We understand you may not be ready to join yet, or that we may not be the right fit, and that's fine. Our goal is to answer your questions and help you decide if the Army is a good option for you. How do I join ROTC at the college I want to attend? Will I be expected to join if I talk to someone? What is the time commitment for part-time service? How can I prepare for the conversation?Ĭan the Army help me pay for medical school? How can the Army help me pay for college?ĭo I have to go to Basic Training? How can I prepare for the conversation? While we'll ask you questions, this is your opportunity to ask some of your own. Expect us to ask about your interests and skills so we can suggest Army jobs that might interest you. From there, the conversation will be about getting to know you and your goals for the future. Our conversation will likely begin with some basic qualifying questions, like your age and education level. One of our ROTC recruiters will either call or email you to set up time to talk. Questions you may have right now Who will reach out to me? , Philadelphia, Detroit, Atlanta, Chicago, Miami, Los Angeles, Seattle, San Francisco, New Orleans, Austin, and New York City. Traveling to other cities with your kiddos? Don’t miss Curbed’s maps of the best family activities in Washington, D.C. And be sure to check the websites and call the phone numbers for any special hours or offers. This is one of the most famous sites in all of Boston, and it’s also one of the best places to get a view of the city. Blend together history and shopping by visiting popular Faneuil Hall Marketplace on Bostons historic Freedom Trail. Try the chowder at Bostons oldest restaurant, head to the Italian-accented North End for cannoli and pizza, or snack on hot dogs in the stands at Fenway Park. See something we missed? Leave a comment below. We’ve mapped 23 of the best kid-friendly activities in the Boston region during wintertime that will please locals and visitors alike. But in Boston and its surrounding region, everything is a bit more doable for families: The top sites are often clustered together or just a short ride away on the city’s subway, buses, and commuter rail. Other great metropolitan areas boast world-renowned museums, gorgeous green spaces, and zoos that keep kids coming back again and again. This makes the Boston region especially easy to visit and to navigate with kids, including around the holidays. Boston is a wonderful city for family travel there are so many options for things to do in Boston with kids. Similarly pedestrian-friendly cities such as Cambridge surround it, too. Because of its compact, historic neighborhoods and bucolic New England waterfront, Boston is probably America’s greatest walking city. |
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